Luiz LC, Marson FAL, Bresciani Almeida CC, Toro A, Nucci A, Ribeiro JD. Analysis of motor and respiratory function in Duchenne muscular dystrophy patients. Respiratory physiology & neurobiology 2019;262:1-11
Study looking at the respiratory and skeletal muscle function in a small group of DMD patients. The study does not really add anything to what is already known. They conclude that the functions are lower compared to the control group, but that is obvious.
INTRODUCTION: Duchenne muscular dystrophy(DMD) shows motor and respiratory impairment.
METHODS: 19 DMD patients(DMDG) (nine ambulatory and 10 non-ambulatory) were evaluated through motor function measure(MFM), 6-minute walk test(6MWT), respiratory muscle strength, cough peak flow, spirometry and volumetric capnography(VCap) tools. Control group that performed spirometry and VCap(CG1-n = 17) were different from those that performed the 6MWT(CG2-n = 8).
RESULTS: The follow tools were assessed (p < 0.05): (i)-MFM: Ambulatory patients showed higher values than non-ambulatory patients; (ii)-6MWT: DMDG walked a shorter distance and showed higher respiratory rate at rest and heart rate(HR) at rest than CG2; (iii)-Spirometry: DMDG and non-ambulatory patients had minor values achieved in spirometry when compared with CG1 and ambulatory patients, respectively; (iv)-VCap: DMDG when compared with CG1 showed: (<11 years-old) lower values in VCap parameters; (>11 years-old): higher HR and lower slope 2. There was correlation between spirometry, mainly for zFEV1/FVC, and MFM.
CONCLUSION: DMDG showed motor (MFM/6MWT) and respiratory (spirometry/VCap) deterioration when compared with CG. Non-ambulatory condition was associated with worse MFM and spirometry.