Duchenne and Becker

Duchenne (DMD) and Becker muscular dystrophy (BMD) are both genetic diseases. People with Duchenne or Becker are born with a change – or mutation – in the gene that produces dystrophin, a protein that protects muscles. 70% of mothers of DMD and BMD patients do not have the disease themselves but are carriers of the mutation and pass it to their child; 30% of the time, the mutation happens spontaneously.

Living with Duchenne muscular dystrophy means tiny losses every day. Losing muscle cells, strength, functions, the ability to walk, and ultimately losing the ability to breathe. Duchenne is a dystrophinopathy, and is one of two diagnoses (Duchenne and Becker muscular dystrophy) that is caused by a mutation in the gene that encodes for a protein called dystrophin. Without dystrophin, muscles are not able to function or repair themselves properly. Becker muscular dystrophy, which is less severe than Duchenne, occurs when dystrophin is manufactured, but not in the normal form or amount. Living with Duchenne also means trying to make the best out of every day, trying to find solutions and hoping for therapeutic innovations, novel treatment options, and new medicines that may alter the progression of the disease.

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