Intelligence and Duchenne muscular dystrophy: full-scale, verbal, and performance intelligence quotients

Cotton S, Voudouris NJ, Greenwood KM. Intelligence and Duchenne muscular dystrophy: full-scale, verbal, and performance intelligence quotients. Developmental medicine and child neurology 2001;43:497-501

CottonGreenwoodJul2001(11463183)

 

Abstract

Duchenne muscular dystrophy (DMD) is a disease which has as its hallmarks progressive muscle weakness and degeneration of skeletal muscle. Also observed among those with DMD is a higher rate of mental retardation* than in the normally developing population.
While estimates for the prevalence of mental retardation in the normally developing population are approximately 9%, estimates of mental retardation based on the administration of the Wechsler Intelligence Scales (WIS) or the Stanford-Binet to children with DMD have ranged from 20% to as high as 50% in some studies. There have been intermittent review articles focusing on this issue, with authors noting aspects of the prevalence discrepancy, but no large-scale collation of the considerable published DMD intelligence data has yet been undertaken. The purpose of this paper is to provide an up-to-date review of this literature, and to report, as well as to summarize, the preliminary results of a metaanalysis of the available data, focusing on on global intelligence measures and DMD.

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