Renal dysfunction can occur in advanced stage Duchenne muscular dystrophy

Motoki T, Shimizu-Motohashi Y, Saito I, et al. Renal dysfunction can occur in advanced stage Duchenne muscular dystrophy. Muscle & nerve 2019

Abstract

INTRODUCTION: With improved treatments, patients with Duchenne muscular dystrophy (DMD) can survive far beyond adolescence. However, advanced stage DMD patients are at risk of developing renal dysfunction. In this study, long-term renal function outcomes and associated risk factors in advanced stage DMD were analyzed.

METHODS: Fifty-one patients were classified into 3 different age groups (<20, 20-29, and >/=30 years old), and cystatin C (CysC) levels were compared among groups.

RESULTS: Median serum CysC levels were 0.74 mg/L, 0.63 mg/L, and 0.76 mg/L in the <20, 20-29, and >/=30 years old groups, respectively (p = 0.003). Five of the 9 patients in the >/=30 year age group showed elevated serum CysC and decreased cardiac function compared with the other 4 (p = 0.014).

DISCUSSION: Our results indicate an association between cardiac and renal dysfunction in patients with advanced stage DMD.

Leave a Reply

search previous next tag category expand menu location phone mail time cart zoom edit close